I had a "slap me-self on the forehead" moment when I read this piece from Mr. RevolverGuy at the Day At The Range blog on his Ruger Alaskan .454:
At this point there was only one last thing to do, turn this revolver into the most versatile revolver I own, capable of being deployed in any situation. Since the original purchase, even before the background check was complete I was thinking Triple Threat. A revolver capable of firing 45ACP, 45LC and 454Casull. This would mean I would need to find someone I could trust to mill the cylinder on my revolver to take 45ACP moon clips.
That is absolutely totally cool! Adding .45 ACP capability, especially with moon clips, really brings the Alaskan up another level. I usually keep .45 Colt ammo around, but I've got tons of .45 ACP. I may have to give this a shot.